Ultra duration numbing is a fast-acting, effective anesthetic. It provides quick pain relief and reduces swelling while blocking nerve conduction. The product must be applied twice to three times throughout the procedure to maximize comfort. It is effective even when used on broken skin.
Quick pain relief:
An ultra-duration topical anesthetic is a reversible anesthetic that blocks nerve conduction near the administration site. It targets the free nerve endings in the dermis and mucosa and causes a temporary loss of sensation over a small area. It works by decreasing the permeability of nerve cell membranes to sodium ions. This sodium decreases the ability to generate action potentials and depolarizes the nerve cell membrane.
Ultra duration is a topical anesthetic that provides quick pain relief and reduces swelling in minutes. It can be used for various procedures, including paramedical tattooing, permanent makeup, and microblading. This product is formulated with 2% Tetracaine, which helps shrink blood vessels and reduce swelling.
Blocks nerve conduction:
Ultra-duration topical anesthetic blocks nerve conductance by affecting the afferents’ action potential waveforms. This anesthetic can block 98% of non-nociceptive ass-fibers, 82% of Ad-fibers, and 46% of C-fibers. This blocking is immediate in many afferents and occurs during the anodal phase. However, many of these afferents resume firing after the treatment is stopped. Another population of afferents had a gradual reduction in firing before complete blocking and delayed recovery after ULF was stopped.
Topical anesthetics have become a routine part of clinical practice. They reduce pain associated with superficial dermatological and aesthetic procedures, minor surgeries, and venipuncture. However, they can have adverse effects, including cardiovascular complications. They should be used with caution and by the recommended dosage.
Topical anesthetics block nerve conduction near the application site by decreasing the permeability of nerve cells to sodium ions. This change in permeability can compete with calcium binding sites and decrease the depolarization and excitability threshold. Once nerve impulse conduction is blocked, the nerve cell can no longer generate action potentials, thus causing the sensation to be lost.
Ultra-duration topical anesthetic (UDTA) is a topical anesthetic that provides quick pain relief and reduces swelling within minutes. The product contains 2% Tetracaine and is suitable for use on open skin. It is not recommended for use on eyelids or closed skin.